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Publications

Research and Development

  • Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality. Drugs Real World Outcomes. 2022 Sep;9(3):359-375 [weblink]
    Miller, G.M., Ellis, J.A., Sarangarajan, R., Parikh, A., Rodrigues, L.O., Bruce, C., Chand, N.M., Smith, S.R., Richardson, K., Vazquez, R., Kiebish, M.A., Haneesh, C., Granger, E., Holtz, J., Hinkle, J., Narain, N.R., Goodpaster, B., Smith, J.C., Lupu, D.S.
  • The Next Frontier: Translational Development of Ubiquitination, SUMOylations, and NEDDylation in Cancer. International Journal of Molecular Sciences, Special Issue Ubiquitination in Health and Diseases: Volume II. 2022 Mar 23;23(7):3480 [weblink]
    Pellegrino, N.E., Guven, A., Gray, K., Shah, P., Kasture, G., Nastke, M.D., Thakura, A., Gesta, S., Vishnudas, V.K., Narain, N.R., Kiebish, M.A.
  • Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID19. Applied Science. 2021 Mar 10; 11 (6), 2466 [weblink]
    Kiebish, M.A., Shah, P., Sarangarajan, R., Vishnudas, V.K., Gesta, S., Tekumalla, P.K., Bountra, C., Granger, E., Schadt, E., Rodrigues, L.O., Narain, N.R.
  • In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients. J. Clin Invest. 2021 Oct 1;131(19) [weblink]
    Li, S., Sarangarajan, R., Jun, T., Kao, Y.H., Wang, Z., Hao, K., Schadt, E., Kiebish, M.A., Granger, E., Narain, N.R., Chen, R., Schadt, E.E., Li, L.
  • A Novel Endocrine Role For The BAT-Released Lipokine 12,13 DiHOME to Mediate Cardiac Function. Circulation. 2021 Jan 12; 143(2):145-159 [weblink]
    Pinckard, K.M., Shettigar, V.K, Wright, K.R., Abay, E., Baer, L.A, Vidal, P., Dewal, R.S., Das, D., Duarte-Sanmiguel, S., Arts, P.J., Lehnig, A.C., Bussberg, V., Narain, N.R., Kiebish, M.A., Yi, F., Sparks, L.M., Goodpaster, B.H., Smith, S.R., Pratley, R.E., Lewandoski, E.D., Raman, S.V., Wold, L.E., Gallego-Perez, D., Coen, P.M., Ziolo, M.T., Stanfordm K.I.
  • CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine. 2020 Aug 26: 12(558):eaaz8664 [weblink]
    Wang, C.H., Lundh, M., Fu, A., Kriszt, R., Huang, T.L., Lynes, M.D., Leiria, L.O., Shamsi, F., Darcy, J., Greenwood, B.P., Narain, N.R., Tolstikov, V., Smith, K.L., Emanuelli, B., Chang, Y.T., Hagen, S., Danial, N.N., Kiebish, M.A., Tseng, Y.H.
  • Divergence in the Metabolome Between Natural Aging and Alzheimer’s Disease. Scientific Reports. 2020 Jul 22: 10(1):12171 [weblink]
    Hunsberger, H.C., Greenwood, B.P., Tolstikov, V., Narain, N.R., Kiebish, M.A., Denny, C.A.
  • Prophylatic Ketamine Alters Nucleotide and Neurotransmitter Metabolism In Brain and Plasma Following Stress.  Neuropsychopharmacology. 2018 Aug:43(9):1813-1821 [weblink]
    McGowan, J.C., Hill, C., Mastrodonato, A., LaGamma, C.T., Kitayev, A., Brachman, R.A., Narain, N.R., Kiebish, M.A., Denny, C.A.
  • 12, 13-diHOME: An Exercise Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metabolism. 2018 May 1:27(5):1111-1120 [weblink]
    Stanford, K.I., Lynes, M.D., Takahashi, H., Baer, L.A., Arts, P.J., May, F.J., Lehnig, A.C., Middelbeek, R.J.W., Richard, J.J., So, K., Chen, E.Y., Gao, F., Narain, N.R., Distefano, G., Shettigar, V.K., Hirshman, M.F., Ziolo, M.T., Kiebish, M.A., Tseng, Y.H., Coen, P.M., Goodyear, L.J.
  • The Cold Induced Lipokine 12,13 DiHome Promotes Fatty Acid Transport Into Brown Adipose Tissue. Nature Medicine. 2017 May:23(5):631-637 [weblink]
    Lynes, M.D., Leiria. L.O., Lundh. M., Bartelt. A., Shamsi. F., Huang. T.L., Takahashi. H., Hirshman, M.F., Schlein, C., Lee, A., Baer, L.A., May, F.J., Gao, F., Narain, N.R., Chen, E.Y., Kiebish, M.A., Cypess, A.M., Blüher, M., Goodyear, L.J., Hotamisligil, G.S., Stanford, K.I., Tseng, Y.H.

OMICS Platform Utility / Artificial Intelligence/Informatics Publications Examples

  • Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults.  The Journal of Physiology. 2023 February 22; 601(11):2165-2188 [weblink]

    J. Matthew Hinkley, Gong Xin Yu, Robert A. Standley, Giovanna Distefano, Vladimir Tolstikov, Niven R. Narain, Bennett P. Greenwood, Shraddha Karmacharya, Michael A. Kiebish, Elvis Alvarez Carnero, Fanchao Yi, Rick B. Vega, Bret H. Goodpaster, Stephen J. Gardell and Paul M. Coen

  • ScreenDMT reveals linoleic acid diols replicably associate with BMI and stimulate adipocyte calcium fluxes  bioRxiv. 2023 August 1;2023.07.12.548737 [weblink]

    Jonathan M. Dreyfuss, Vera Djordjilovic, Hui Pan, Valerie Bussberg, Allison M. MacDonald, Niven R. Narain, Michael A. Kiebish, Matthias Blüher, Yu-Hua Tseng Matthew D. Lynes

  • Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia.  Scientific Reports. 2024 January 19;14(1):1729 [weblink]

    Dora Ravasz, David Bui, Sara Nazarian, Gergely Pallag, Noemi Karnok, Jennie Roberts, Bryan P. Marzullo, Daniel A. Tennant, Bennett Greenwood, Alex Kitayev, Collin Hill, Timea Komlódi, Carolina Doerrier, Kristyna Cunatova, Erika Fernandez‑Vizarra, Erich Gnaiger, Michael A. Kiebish, Alexandra Raska, Krasimir Kolev, Bence Czumbel, Niven R. Narain, Thomas N. Seyfried & Christos Chinopoulos

  • Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality. Drugs Real World Outcomes. 2022 Sep;9(3):359-375 [weblink]

    Miller, G.M., Ellis, J.A., Sarangarajan, R., Parikh, A., Rodrigues, L.O., Bruce, C., Chand, N.M., Smith, S.R., Richardson, K., Vazquez, R., Kiebish, M.A., Haneesh, C., Granger, E., Holtz, J., Hinkle, J., Narain, N.R., Goodpaster, B., Smith, J.C., Lupu, D.S.

  • The Next Frontier: Translational Development of Ubiquitination, SUMOylations, and NEDDylation in Cancer. International Journal of Molecular Sciences, Special Issue Ubiquitination in Health and Diseases: Volume II. 2022 Mar 23;23(7):3480 [weblink]

    Pelligrino, N.E., Guven, A., Gray, K., Shah, P., Kasture, G., Nastke, M.D., Thakura, A., Gesta, S., Vishnudas, V.K., Narain, N.R., Kiebish, M.A.

  • Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID19. Applied Science. 2021 Mar 10; 11 (6), 2466 [weblink]

    Kiebish, M.A., Shah, P., Sarangarajan, R., Vishnudas, V.K., Gesta, S., Tekumalla, P.K., Bountra, C., Granger, E., Schadt, E., Rodrigues, L.O., Narain, N.R.

  • In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients. J. Clin Invest. 2021 Oct 1;131(19) [weblink]

    Li, S., Sarangarajan, R., Jun, T., Kao, Y.H., Wang, Z., Hao, K., Schadt, E., Kiebish, M.A., Granger, E., Narain, N.R., Chen, R., Schadt, E.E., Li, L.

  • A Novel Endocrine Role For The BAT-Released Lipokine 12,13 DiHOME to Mediate Cardiac Function. Circulation. 2021 Jan 12; 143(2):145-159 [weblink]

    Pinckard, K.M., Shettigar, V.K, Wright, K.R., Abay, E., Baer, L.A, Vidal, P., Dewal, R.S., Das, D., Duarte-Sanmiguel, S., Arts, P.J., Lehnig, A.C., Bussberg, V., Narain, N.R., Kiebish, M.A., Yi, F., Sparks, L.M., Goodpaster, B.H., Smith, S.R., Pratley, R.E., Lewandoski, E.D., Raman, S.V., Wold, L.E., Gallego-Perez, D., Coen, P.M., Ziolo, M.T., Stanfordm K.I.

  • CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine. 2020 Aug 26: 12(558):eaaz8664 [weblink]

    Wang, C.H., Lundh, M., Fu, A., Kriszt, R., Huang, T.L., Lynes, M.D., Leiria, L.O., Shamsi, F., Darcy, J., Greenwood, B.P., Narain, N.R., Tolstikov, V., Smith, K.L., Emanuelli, B., Chang, Y.T., Hagen, S., Danial, N.N., Kiebish, M.A., Tseng, Y.H.

  • Divergence in the Metabolome Between Natural Aging and Alzheimer’s Disease. Scientific Reports. 2020 Jul 22: 10(1):12171 [weblink]

    Hunsberger, H.C., Greenwood, B.P., Tolstikov, V., Narain, N.R., Kiebish, M.A., Denny, C.A.

  • Prophylatic Ketamine Alters Nucleotide and Neurotransmitter Metabolism In Brain and Plasma Following Stress.  Neuropsychopharmacology. 2018 Aug:43(9):1813-1821 [weblink]

    McGowan, J.C., Hill, C., Mastrodonato, A., LaGamma, C.T., Kitayev, A., Brachman, R.A., Narain, N.R., Kiebish, M.A., Denny, C.A.

  • 12, 13-diHOME: An Exercise Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metabolism. 2018 May 1:27(5):1111-1120 [weblink]

    Stanford, K.I., Lynes, M.D., Takahashi, H., Baer, L.A., Arts, P.J., May, F.J., Lehnig, A.C., Middelbeek, R.J.W., Richard, J.J., So, K., Chen, E.Y., Gao, F., Narain, N.R., Distefano, G., Shettigar, V.K., Hirshman, M.F., Ziolo, M.T., Kiebish, M.A., Tseng, Y.H., Coen, P.M., Goodyear, L.J.

  • The Cold Induced Lipokine 12,13 DiHome Promotes Fatty Acid Transport Into Brown Adipose Tissue. Nature Medicine. 2017 May:23(5):631-637 [weblink]

    Lynes, M.D., Leiria. L.O., Lundh. M., Bartelt. A., Shamsi. F., Huang. T.L., Takahashi. H., Hirshman, M.F., Schlein, C., Lee, A., Baer, L.A., May, F.J., Gao, F., Narain, N.R., Chen, E.Y., Kiebish, M.A., Cypess, A.M., Blüher, M., Goodyear, L.J., Hotamisligil, G.S., Stanford, K.I., Tseng, Y.H.

BIOMARKERS/Precision Medicine Publications Examples

  • Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia from Prostate Cancer in Caucasian and African American Men.  Cancers: Special Issue-Liquid Biopsy of Genitourinary Tumors. 2024 February 8 https://doi.org/10.3390/cancers16040712 [weblink]

    Nischal Mahaveer Chand, Poornima K. Tekumalla, Matt T. Rosenberg, Albert Dobi, Amina Ali,Gregory M. Miller, Juan J. Aristizabal-Henao, Elder Granger, Stephen J. Freedland, Mark D. Kellogg, Shiv Srivastava, David G. McLeod, Niven R. Narain and Michael A. Kiebish

  • Clinical Utility of a Serum Biomarker Panel In Distinguishing Prostate Cancer From Benign Prostate Hyperplasia. Scientific Reports. 2021 Jul 23; 11(1):15052 [weblink]

    Kiebish, M.A., Tekumalla, P., Ravipaty, S., Dobi, A., Srivastava, S., Wu, W., Patil, S., Friss, T., Klotz, A., Srinivasan, A., Cullen, J., Rosner, I.L., Ali, A., Laszlo, S., Petrovic, M., Fleshner, N., Garren, J., Miller, G., Mahaveer Chand N., Rodrigues, L.O., Granger, E., Kellogg, M.D., Luan, S., Diamandis, E., Akmaev, V.R., Sarangarajan, R., Bountra, C., Freedland, S.J., McLeod, D.G., Narain, N.R.

  • Diagnostic Utility of Serum and Urinary Metabolite Analysis in Patients With Interstitial Cystitis/Painful Bladder Syndrome. Urology. 2021 May 17:S0090-4295(21)00395 [weblink] Full text available for purchase.

    Kim, J., De Hoedt. A., Wiggins, E., Haywood, K., Jin, P., Greenwood, B., Narain, N.R., Tolstikov, V., Bussberg, V., Barbour, K.E., Kiebish, M.A., Freedland, S.J., Anger, J.T.

  • Multi-omic Serum Biomarkers For Prognosis of Disease Progression in Prostate Cancer.  Journal of Translational Medicine. 2020 Jan 7: 18(1):10 [weblink]

    Kiebish, M.A., Cullen, J., Mishra, P., Ali, A., Milliman, E., Rodrigues, L.O., Chen, E.Y., Tolstikov, V., Zhang, L., Panagopoulos, K., Shah, P., Chen, Y., Petrovics, G., Rosner, I.L., Sesterhenn, I.A., McLeod, D.G., Granger, E., Sarangarajan, R., Akmaev, V., Srinivasan, A., Srivastava, S., Narain, N.R., Dobi, A.

  • Genomic Alterations of Tenascin C in Highly Aggressive Prostate Cancer: A Meta-analysis. Genes Cancer. 2019:10(5-6):150-159 [weblink] Mishra, P., Kiebish, M.A., Cullen, J., Srinivasan, A., Patterson, A., Sarangarajan, R., Narain, N.R., Dobi, A.