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Research and Development

  • BPM31510 Increases the CoQ Pool in Chemically Induced CoQ-Deficient Cells, CoQ-Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues. FASEB Journal Published: 03 April 2026 [weblink]

  • Establishing the relationship between brain cellular senescence and brain structure. Cell, Volume 189, Issue 2, P511-527, Published: 22 January 2026 [weblink]
  • Oxylipin Responses during the Yukon Arctic Ultra: The Longest and Coldest Ultramarathon in the World. Military Medicine, usaf622, Published: 12 January 2026 [weblink]
  • Phase Ia/b Multicenter Study of BPM31510IV Targeting Mitochondrial Metabolism/Warburg Effect as Monotherapy and Combination Chemotherapy in Solid Tumor Patients, Published: 24 December 2025 [weblink]
  • The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer. Journal of Bioenergetics and Biomembranes, Published: 
  • Superstable lipid vacuoles endow cartilage with its shape and biomechanics. Science, Vol 387, Issue 6730, 2025 Jan 10 [weblink]
  • Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality. Drugs Real World Outcomes. 2022 Sep;9(3):359-375 [weblink]
  • The Next Frontier: Translational Development of Ubiquitination, SUMOylations, and NEDDylation in Cancer. International Journal of Molecular Sciences, Special Issue Ubiquitination in Health and Diseases: Volume II. 2022 Mar 23;23(7):3480 [weblink]
  • Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID19. Applied Science. 2021 Mar 10; 11 (6), 2466 [weblink]
  • In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients. J. Clin Invest. 2021 Oct 1;131(19) [weblink]
  • A Novel Endocrine Role For The BAT-Released Lipokine 12,13 DiHOME to Mediate Cardiac Function. Circulation. 2021 Jan 12; 143(2):145-159 [weblink]
  • CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine. 2020 Aug 26: 12(558):eaaz8664 [weblink]
  • Divergence in the Metabolome Between Natural Aging and Alzheimer’s Disease. Scientific Reports. 2020 Jul 22: 10(1):12171 [weblink]
  • Prophylatic Ketamine Alters Nucleotide and Neurotransmitter Metabolism In Brain and Plasma Following Stress.  Neuropsychopharmacology. 2018 Aug:43(9):1813-1821 [weblink]
  • 12, 13-diHOME: An Exercise Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metabolism. 2018 May 1:27(5):1111-1120 [weblink]
  • The Cold Induced Lipokine 12,13 DiHome Promotes Fatty Acid Transport Into Brown Adipose Tissue. Nature Medicine. 2017 May:23(5):631-637 [weblink]

OMICS Platform Utility / Artificial Intelligence/Informatics Publications Examples

  • Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults.  The Journal of Physiology. 2023 February 22; 601(11):2165-2188 [weblink]
  • ScreenDMT reveals linoleic acid diols replicably associate with BMI and stimulate adipocyte calcium fluxes  bioRxiv. 2023 August 1;2023.07.12.548737 [weblink]
  • Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia.  Scientific Reports. 2024 January 19;14(1):1729 [weblink]
  • Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality. Drugs Real World Outcomes. 2022 Sep;9(3):359-375 [weblink]
  • The Next Frontier: Translational Development of Ubiquitination, SUMOylations, and NEDDylation in Cancer. International Journal of Molecular Sciences, Special Issue Ubiquitination in Health and Diseases: Volume II. 2022 Mar 23;23(7):3480 [weblink]
  • Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID19. Applied Science. 2021 Mar 10; 11 (6), 2466 [weblink]
  • In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients. J. Clin Invest. 2021 Oct 1;131(19) [weblink]
  • A Novel Endocrine Role For The BAT-Released Lipokine 12,13 DiHOME to Mediate Cardiac Function. Circulation. 2021 Jan 12; 143(2):145-159 [weblink]
  • CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine. 2020 Aug 26: 12(558):eaaz8664 [weblink]
  • Divergence in the Metabolome Between Natural Aging and Alzheimer’s Disease. Scientific Reports. 2020 Jul 22: 10(1):12171 [weblink]
  • Prophylatic Ketamine Alters Nucleotide and Neurotransmitter Metabolism In Brain and Plasma Following Stress.  Neuropsychopharmacology. 2018 Aug:43(9):1813-1821 [weblink]
  • 12, 13-diHOME: An Exercise Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metabolism. 2018 May 1:27(5):1111-1120 [weblink]
  • The Cold Induced Lipokine 12,13 DiHome Promotes Fatty Acid Transport Into Brown Adipose Tissue. Nature Medicine. 2017 May:23(5):631-637 [weblink]

BIOMARKERS/Precision Medicine Publications Examples

  • Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson’s disease biomarker panel. Scientific Reports. 2024 May 02; 14:10036 [weblink]

  • Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia from Prostate Cancer in Caucasian and African American Men.  Cancers: Special Issue-Liquid Biopsy of Genitourinary Tumors. 2024 February 8 [weblink]
  • Clinical Utility of a Serum Biomarker Panel In Distinguishing Prostate Cancer From Benign Prostate Hyperplasia. Scientific Reports. 2021 Jul 23; 11(1):15052 [weblink]
  • Diagnostic Utility of Serum and Urinary Metabolite Analysis in Patients With Interstitial Cystitis/Painful Bladder Syndrome. Urology. 2021 May 17:S0090-4295(21)00395 [weblink] Full text available for purchase.
  • Multi-omic Serum Biomarkers For Prognosis of Disease Progression in Prostate Cancer.  Journal of Translational Medicine. 2020 Jan 7: 18(1):10 [weblink]
  • Genomic Alterations of Tenascin C in Highly Aggressive Prostate Cancer: A Meta-analysis. Genes Cancer. 2019:10(5-6):150-159 [weblink]