What is Pancreatic Cancer?
Pancreatic Cancer is a disease with a high unmet medical need. In 2017, an estimated 53,070 adults in the United States will be diagnosed with Pancreatic Cancer. The majority of Pancreatic Cancer cases are diagnosed late, at which point the disease is already locally advanced or metastatic.
The disease accounts for about 3 percent of all cancers in the US and is the third leading cause of cancer death in men and women according to the American Cancer Society.
BPGbio’s Pancreatic Cancer drug candidate (BPM31510) has received FDA Orphan-Drug Designation.
BPGbio’s Pancreatic Cancer drug candidate (BPM31510) has received FDA Orphan-Drug Designation.
What is BPGbio’s current prospect for treatment?
BPGbio’s BPM31510 is an intravenous formulation of ubidecarenone (coenzyme Q10) in clinical development for several cancers including the treatment of advanced pancreatic cancer.
How does BPGbio’s potential treatment work?
Cancer cells alter metabolism to generate energy from non-mitochondrial pathways to support uncontrolled growth. This allows the cancer cells to escape molecular mechanisms controlling cell death. BPGbio’s BPM31510 is a first in class molecule that specifically targets the dysregulated metabolism observed in cancer.
BPGbio’s BPM31510 is designed to act by targeting metabolism in cancer cells in a way that may help re-engage mitochondrial energy production, potentially shifting metabolism toward patterns more consistent with those observed in normal cells. Preclinical and clinical observations suggest that this metabolic modulation could be associated with the reactivation of pathways involved in detecting cell damage, which in turn may contribute to apoptosis, or programmed cell death.
BPM31510 Pancreatic Cancer Clinical Trial Status
The Phase 2 clinical trial for BPGbio’s Pancreatic Cancer drug candidate (BPM31510) is complete.
For more information about BPGbio’s BPM31510 Pancreatic Cancer trial, please click here.
BPM31510 is not yet approved by the FDA.
Pancreatic Cancer Clinical & Scientific Posters
For more posters head to our poster archive here.
