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Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Cell Metabolism 28, 1–16

Authors: Elahu G. Sustarsic, Tao Ma, Matthew D. Lynes, Yu-Hua Tseng, Nils J. Færgeman, Zachary Gerhart-Hines

Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.

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