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Cell Metabolism:12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

Stanford et al., 2018, Cell Metabolism 27, 1111–1120 May 1, 2018 ª 2018 Elsevier Inc.

Authors: Kristin I. Stanford, Matthew D. Lynes, Hirokazu Takahashi, Yu-Hua Tseng, Paul M. Coen, Laurie J. Goodyear

Using an MS/MSALL lipidomics platform, Stanford et al. identify 12,13-diHOME as an exercised-induced lipokine in male, female, young, and old human subjects. Murine experiments show that BAT is the tissue source of exercise-induced increases in circulating 12,13-diHOME, and that this lipokine increases fatty acid uptake in skeletal muscle in vivo.

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